The first apparent use of the name Glendale was the Glendale Grange formed in 1896. In 1902, William Harold Baumert named his dairy the Glendale Farm Dairy. This dairy was on the southeast corner of Quebec and Leetsdale… thus, the term Glendale was used to describe the community. 

In 1859, the Territorial Road came down Cherry Creek Valley past the Four Mile House and through Glendale. The Four Mile House was one of the stage stops along the road, becoming a way station for freight wagons and a stock ranch. Independent dairies were prevalent in Glendale beginning in the late 1880s.

An interesting site on the edge of Glendale is Four Mile Historic Park. This 12-acre rural site is home to metropolitan Denver's oldest house, the Four Mile House, which is listed on the National Register of Historic Places. Built in 1859 along Cherry Creek, the Four Mile House once served as a stage stop, wayside inn, and tavern for travelers on their way to Denver City via the Cherokee Trail. Today Four Mile Historic Park houses a museum, summer camp, and events center. The park is situated just outside Glendale's city limits.

A fossil was found in 1937 in the sands of the bed of Cherry Creek, the first evidence of prehistoric animals. Later that year, an upper molar of a mammoth was found and donated to Denver’s Museum of Natural History. In 1948, the last horse-drawn milk wagon was retired at City Park Dairy.

January 8, 1952 was the date of the original filing for incorporation of the Town of Glendale. In May 1960, the Town was authorized to purchase vehicles to be used by the Marshal and Deputy Marshal. Glendale voted to adopt a home rule type of government in March of 1972.

The Event Center is a sophisticated destination for meetings, trade shows, social galas, non-profit gatherings, weddings and fashion shows. With four outdoor spaces and four indoor spaces, totaling 145,150 square feet, Infinity Park can accommodate up to 13,223 outside and 1,495 inside. Infinity Park provides endless possibilities to make a lasting impression.